Not intoxicated high, but surviving the challenges of high altitude.
It’s cold, the air is thin — at 12,000 feet there is only 60% as much oxygen as there is at sea level, there is little food for animals that live this high, and there are strong winds and extreme weather. Starkly beautiful, but potentially fatal if not appropriately adapted.
So, how do animals cope with these challenges survive at high altitude?
The temperature: animals stay warm with their heavy fur coats; hikers generally wear a number of layers, adding or peeling them off as the air temperature dictates.
The lack of food: summer is usually a productive period, even at high altitude, and animals cash in on this bounty by stockpiling resources (e.g., the pika collecting forage to turn it into hay or squirrels collecting nuts), or they consume so many calories during the summer, they are able to lay on an extra amount of fat to carry them through the winter while they hibernate. Hikers carry their food around with them, and the added weight places an additional strain on the demand for oxygen.
The lack of oxygen: Now this is where the real macho high altitude physiology comes into play. Animals (and humans) native to high altitude have bigger hearts, bigger lungs, more red blood cells, more oxygen-carrying hemoglobin, more capillary beds to carry oxygen to their muscles and other tissues, and a host of other biochemical advantages that their low altitude relatives lack.
High altitude human hikers are limited in how far they can push their own biochemistry in the adapted direction. We can’t grow larger organs, but we can make more red blood cells and hemoglogbin (it takes about three weeks though), and we can develop new capillary beds to tissues. We can modify our biochemical enzymes slightly, but not to the degree that high altitude natives do. However, these adjustments take time — much longer than 1-2 days, which makes our occasional visits to hike at high altitude problematic.You can read or view more about this subject at the BBC Nature website on High Altitude.